CD11a Antibody [DF1524]
Product Specifications
Background
Recognizes a protein of 180kDa, identified as CD11a (Leucocyte Workshop IV; Code 1524) . CD11a complex with the 2 subunit of the integrin family, CD18, to form the cell surface heterodimer, LFA-1 or CD11a /C18 (aLbL) . LFA-1 is expressed on all leukocytes including lymphocytes, monocytes, and granulocytes. It is involved in leukocyte adhesion to its ligands including intercellular adhesion molecule-1 (ICAM-1 or CD54), ICAM-2 (CD102), ICAM-3 (CD50) and Telencephalin (TLN) and play a role in most immune/inflammatory responses. This mAb potently blocks LFA-1 dependent homotypic cell aggregation.
NCBI Gene ID
3683
Swiss Prot
P20701
Host
Mouse
Reactivity
Human
Immunogen
Human CD11a protein was used as the immunogen for the CD11a antibody.
Clonality
Monoclonal
Clone
DF1524
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
Protein G affinity chromatography
Concentration
0.2 mg/mL
Buffer
PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Fragment
IgG2b, kappa
Symbol
ITGAL
NCBI Official Name
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
NCBI Organism
Homo sapiens
Other Product Names
Integrin alpha-L, CD11 antigen-like family member A, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, CD11a, ITGAL, CD11A
Tested Applications
WB, Flow, IF, Functional Assays
Physical Properties
Liquid
Frequently Asked Questions
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