COX18 Antibody

COX18 is required for the insertion of integral membrane proteins into the mitochondrial inner membrane. COX18 is essential for the activity and assembly of cytochrome c oxidase. COX18 plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space.COX18 encodes a cytochrome c oxidase (COX) -assembly protein. The S. cerevisiae Cox18 protein catalyzes the insertion of the Cox2 (MTCO2; MIM 516040) C-terminal tail into the mitochondrial inner membrane, an intermediate step in the assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]) .

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store COX18 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

COX18 antibody can be used for detection of COX18 by ELISA at 1:1562500. COX18 antibody can be used for detection of COX18 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.