MEDI0639
Product Specifications
Target
Gamma-secretase
Related Pathways
Proteases/Proteasome, Stem Cells, Neuroscience
Bioactivity
MEDI0639 (21H3RK) is a human monoclonal antibody (mAb) targeting DLL4. It inhibits the interaction between Notch1 and Dll4 and reverses Notch1-mediated inhibition of in vitro human umbilical vein endothelial cell growth. Additionally, MEDI0639 enhances human angiogenesis and reduces the number of smooth muscle actin-positive mural cell-covered vessels. This compound can be used in research on small cell lung cancer and solid tumors.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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