KLB Antibody
Product Specifications
Background
KLB is a single-pass type III membrane protein. It contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. KLB is probably inactive as a glycosidase. It increases the ability of FGFR1 and FGFR4 to bind FGF21.
NCBI Gene ID
152831
Swiss Prot
Q86Z14
Accession Number
NP_783864
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KLB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
721_B Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store KLB antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=26-776
Calculated Molecular Weight
120 kDa
Applications Notes
KLB antibody can be used for detection of KLB by ELISA at 1:12500. KLB antibody can be used for detection of KLB by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
KLB
NCBI Official Name
Klotho beta
NCBI Organism
Homo sapiens
Background Reference 01
Lu, L., (2008) Cancer Invest. 26 (2), 185-192.
Other Product Names
KLB, BKL, MGC142213
Tested Applications
ELISA, WB
Protein ID
28376633
Physical Properties
Liquid
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