KCNJ3 Antibody

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins.

GIRK1, KGA, KIR3.1, G protein-activated inward rectifier potassium channel 1, GIRK-1, inward rectifier K (+) channel Kir3.1, inward rectifier K+ channel KIR3.1, potassium channel, inwardly rectifying subfamily J member 3, potassium inwardly-rectifying channel subfamily J member 3 splice variant 1e, potassium inwardly-rectifying channel, subfamily J, member 3