DUSP1 / MKP1 Antibody
Product Specifications
Background
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
NCBI Gene ID
1843
Swiss Prot
P28562
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human DUSP1 / MKP1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Affinity purification
Positive Control
HepG2
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=18-871
Calculated Molecular Weight
Observed: 49kDa
Fragment
IgG
Symbol
DUSP1
Positive Control 2
BT-474
Positive Control 3
Mouse brain
NCBI Official Name
Dual specificity phosphatase 1
NCBI Organism
Homo sapiens
Other Product Names
DUSP1, dual specificity phosphatase 1, HVH1, CL100, MKP-1, PTPN10, serine/threonine specific protein phosphatase, MKP1, VH1
Tested Applications
WB, IF
Physical Properties
Liquid
Curated Selection
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