Uhrf2 Antibody

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.

2310065A22Rik, AI42627AW214556, D130071B19Rik, Nirf, E3 ubiquitin-protein ligase UHRF2, Np95-like ring finger protein, RING-type E3 ubiquitin transferase UHRF2, nuclear protein 97, nuclear zinc finger protein Np97, ubiquitin-like PHD and RING finger domain-containing protein 2, ubiquitin-like-containing PHD and RING finger domains protein 2