TFEB Antibody

Product Specifications

Background

The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors (1,2) . Recent studies have shown that lysosomal biogenesis is regulated by TFEB (3), which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1 (4) . Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes (5) .

NCBI Gene ID

7942

Swiss Prot

P19484

Accession Number

NP_009093

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Autophagy

Purification

TFEB antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 10-101 - Human Lung Tissue Slide

Concentration

1 mg/mL

Buffer

TFEB antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TFEB antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Fragment

IgG

Specificity

TFEB antibody is human specific. At least three isoforms of TFEB are known to exist.

Symbol

TFEB

NCBI Official Name

Transcription factor EB

NCBI Organism

Homo sapiens

Background Reference 01

Carr CS and Sharp PA. A helix-loop-helix protein related to the immunoglobulin E box-binding proteins. Mol. Cell Biol. 1990; 10:4384-8.

Background Reference 02

Davis IJ, Hsi BL, Arroyo JD, et al. Cloning of an alpha-TFEB fusion in renal tumors harboring the t (6;11) (p21; q13) chromosome translocation. Proc. Natl. Acad. Sci. USA 2003; 100:6051-6.