IL-23 Antibody

Product Specifications

Background

IL-23 Antibody: Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-α from activated T cells, and can stimulate macrophages to produce TNF-α and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.

NCBI Gene ID

51561

Swiss Prot

Q9NPF7

Accession Number

AAH66268

Host

Rabbit

Reactivity

Human

Immunogen

3793

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Recombinant Protein Test (Figure 3) : Anit-IL-23 antibodies (3793) detected human IL-23 recombinant protein. Recombinant Protein Test3793 Regulated expression validation (Figure 8) : IL-23 expression detected by anit-IL-23 antibodies (3793) was abundant in human abdominal aortic aneurysm (AAA) tissues whereas there is no IL-23 expression in normal tissue. Regulated expression validation3793

Field of Research

Immunology, Chemokines & Cytokines

Purification

IL-23 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1207 - Raji Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Guinea pig: (93%), Horse: (93%), Mouse: (71%), Rat: (71%)

Buffer

IL-23 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

IL-23 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Isoform

Human IL-23 has one isoform (189aa, 20.7kD) . Mouse IL-23 has one isoform (196aa, 22.1kD) and Rat IL-23 also has one isoform (196aa, 22kD) . 3793 can detect human IL-23.

Symbol

IL23A

Positive Control 2

Cat. No. 11-101 - Human Pancreas Tissue Slide

Positive Control 3

Cat. No. 17-007 - Raji Cell Slide

NCBI Official Name

Interleukin 23, alpha subunit p19

NCBI Organism

Homo sapiens

Background Reference 01

Hunter. Nat. Rev. Immunol. 2005; 5:521-31.

Background Reference 02

Oppmann et al. Immunity 2000; 13:715-25.

Background Reference 03

Sheibanie et al. FASEB J. 2004; 18:1318-20.

Background Reference 04

Pirhonen et al. J. Immunol. 2002; 169:5673-8.

Citation 01

31320700

Other Product Names

IL-23 Antibody: P19, SGRF, IL-23, IL-23A, IL23P19, UNQ2498/PRO5798, Interleukin-23 subunit alpha, Interleukin-23 subunit p19, IL-23 subunit alpha

Tested Applications

ELISA, WB, IHC-P, ICC, IF

Protein ID

42542809

Physical Properties

Liquid

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

SR308933 1 Kit

NADE (BEX3) Human siRNA Oligo Duplex (Locus ID 27018)

Ask

View Details

PM45866M5 20 µg

Nsun2 (BC013625) Mouse Recombinant Protein

Ask

View Details

MG202484 10 µg

Caln1 (NM_021371) Mouse Tagged ORF Clone

Ask

View Details

227088-PE 100 µL

Myoglobin (PE)

Ask

View Details

abx033487-01 80 µL

Cullin 5 (CUL5) Antibody

Ask

View Details

abx033487-02 400 µL

Cullin 5 (CUL5) Antibody

Ask

View Details