OGDH (NM_002541) Human Recombinant Protein
Product Specifications
Background
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO (2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
Overview
Recombinant protein of human oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (OGDH), nuclear gene encoding mitochondrial protein, transcript variant 1
Synonyms
AKGDH; E1k; KGD1; OGDC; OGDH2
Gene ID
4967
UniProt
Q02218, B4E3E9
Accession Number mRNA
NM_002541
Chromosomal Location
7p13
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Citrate cycle (TCA cycle), Lysine degradation, Metabolic pathways, Tryptophan metabolism
Field of Research
Citrate cycle (TCA cycle), Lysine degradation, Metabolic pathways, Tryptophan metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
111.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
OGDH
Species
Human
Protein ID
NP_002532
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4967
Uniprot URL
https://www.uniprot.org/uniprot/Q02218
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002541
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002532
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