CK0683A
CK0683A is a novel biaminourea antibiotic with antiplaque effects and demonstrated efficacy in experimental mouse dental disease models. A 12-week study in beagles compared its efficacy in terms of plaque and gingivitis reduction, staining potential, and safety. Dogs were selected as the study subjects because the onset and progression of canine periodontal disease is similar to that of humans. As a positive control for plaque and gingivitis reduction and staining, chlorhexidine acetate was selected because it is effective in both humans and dogs.
Product Specifications
CAS Number
83539-21-3
UNSPSC
12352211
Target
Antibiotic
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ck0683a.html
Smiles
O=C(NC12CC3CC(C2)CC(C1)C3)NC(NCCCN(CCCNC(NC(NC45CC6CC(C5)CC(C4)C6)=O)=N)C)=N.O=S(O)(C)=O
Molecular Formula
C32H57N9O5S
Molecular Weight
679.92
References & Citations
[1]Basic Biological Sciences: Effects of Chlorhexidine and Four Antimicrobial Compounds on Plaque, Gingivitis, and Staining in Beagle Dogs
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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