RhoGDI (ARHGDIA) (NM_004309) Human Recombinant Protein
Product Specifications
Background
This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Synonyms
GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1
Gene ID
396
UniProt
P52565, V9HWE8
Accession Number mRNA
NM_004309
Chromosomal Location
17q25.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Neurotrophin signaling pathway
Field of Research
Neurotrophin signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
23 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ARHGDIA
Species
Human
Protein ID
NP_004300
Overview
Recombinant protein of human Rho GDP dissociation inhibitor (GDI) alpha (ARHGDIA)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/396
Uniprot URL
https://www.uniprot.org/uniprot/P52565
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004309
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004300
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