Epac2 (RAPGEF4) (NM_007023) Human Recombinant Protein
Product Specifications
Background
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity) .[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human Rap guanine nucleotide exchange factor (GEF) 4 (RAPGEF4), transcript variant 1
Synonyms
CAMP-GEFII; CGEF2; EPAC; EPAC 2; EPAC2; Nbla00496
Gene ID
11069
UniProt
Q8WZA2
Accession Number mRNA
NM_007023
Chromosomal Location
2q31.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Leukocyte transendothelial migration
Field of Research
Leukocyte transendothelial migration
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
115.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RAPGEF4
Species
Human
Protein ID
NP_008954
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/11069
Uniprot URL
https://www.uniprot.org/uniprot/Q8WZA2
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_007023
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_008954
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