C20orf11 (GID8) (NM_017896) Human Recombinant Protein
Product Specifications
Background
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972) . Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046) .[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human chromosome 20 open reading frame 11 (C20orf11)
Synonyms
C20orf11; TWA1
Gene ID
54994
UniProt
Q9NWU2
Accession Number mRNA
NM_017896
Chromosomal Location
20q13.33
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
26.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
GID8
Species
Human
Protein ID
NP_060366
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/54994
Uniprot URL
https://www.uniprot.org/uniprot/Q9NWU2
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_017896
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_060366
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