C20orf11 (GID8) (NM_017896) Human Recombinant Protein

Product Specifications

Background

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972) . Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046) .[UniProtKB/Swiss-Prot Function]

Overview

Recombinant protein of human chromosome 20 open reading frame 11 (C20orf11)

Synonyms

C20orf11; TWA1

Gene ID

54994

UniProt

Q9NWU2

Accession Number mRNA

NM_017896

Chromosomal Location

20q13.33

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

26.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.