SIGLEC5 (NM_003830) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig) -like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]
Synonyms
CD33L2; CD170; OB-BP2; OBBP2; SIGLEC-5
Gene ID
8778
UniProt
O15389
Accession Number mRNA
NM_003830
Chromosomal Location
19q13.41
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
60.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SIGLEC5
Species
Human
Protein ID
NP_003821
Overview
Recombinant protein of human sialic acid binding Ig-like lectin 5 (SIGLEC5)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8778
Uniprot URL
https://www.uniprot.org/uniprot/O15389
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003830
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003821
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