Cullin 4B (CUL4B) (NM_003588) Human Recombinant Protein
Product Specifications
Background
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms
CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2
Gene ID
8450
UniProt
Q13620
Accession Number mRNA
NM_003588
Chromosomal Location
Xq24
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Nucleotide excision repair, Ubiquitin mediated proteolysis
Field of Research
Nucleotide excision repair, Ubiquitin mediated proteolysis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
103.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CUL4B
Species
Human
Protein ID
NP_003579
Overview
Recombinant protein of human cullin 4B (CUL4B), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8450
Uniprot URL
https://www.uniprot.org/uniprot/Q13620
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003588
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003579
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