Cullin 4B (CUL4B) (NM_003588) Human Recombinant Protein

Product Specifications

Background

This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human cullin 4B (CUL4B), transcript variant 1

Synonyms

CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2

Gene ID

8450

UniProt

Q13620

Accession Number mRNA

NM_003588

Chromosomal Location

Xq24

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Nucleotide excision repair, Ubiquitin mediated proteolysis

Field of Research

Nucleotide excision repair, Ubiquitin mediated proteolysis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

103.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.