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(R) -Lanicemine

(R) -Lanicemine ((R) -AZD6765) is the less active R-enantiomer of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively) . Antidepressant effects[1].

Product Specifications

CAS Number

[190581-71-6]

Product Name Alternative

(R) -AZD6765

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/r-lanicemine.html

Solubility

10 mM in DMSO

Smiles

N[C@@H](C1=CC=CC=C1)CC2=CC=CC=N2

Molecular Formula

C13H14N2

Molecular Weight

198.26

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19 (9) :978-85.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NMDA Receptor

Available Sizes

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