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TRAF3 (NM_003300) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020]

Overview

Recombinant protein of human TNF receptor-associated factor 3 (TRAF3), transcript variant 3

Synonyms

CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1; RNF118

Gene ID

7187

UniProt

Q13114

Accession Number mRNA

NM_003300

Chromosomal Location

14q32.32

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Pathways in cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, Toll-like receptor signaling pathway

Field of Research

Pathways in cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, Toll-like receptor signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

64.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

TRAF3

Species

Human

Protein ID

NP_003291

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/7187

Uniprot URL

https://www.uniprot.org/uniprot/Q13114

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_003300

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_003291

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