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AXL (NM_021913) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6) . This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Overview

Purified recombinant protein of human AXL receptor tyrosine kinase (AXL), transcript variant 1, with C-terminal DDK/His tag, expressed in human cells, 20 µg

Synonyms

ARK; JTK11; Tyro7; UFO

Gene ID

558

UniProt

P30530

Accession Number mRNA

NM_021913

Chromosomal Location

19q13.2

Expression System

HEK293

Tag

C-DDK/His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

PBS, pH7.4, 10% glycerol

Function

Druggable Genome, Protein Kinase, Transmembrane

Molecular Weight

49 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

AXL

Species

Human

Protein ID

NP_068713

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/558

Uniprot URL

https://www.uniprot.org/uniprot/P30530

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_021913

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_068713

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