CD41 Recombinant Rabbit Monoclonal Antibody [PSH08-02]
Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. At least 38 disease-causing mutations in this gene have been discovered. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
Itga2b
Swiss Prot
Q9QUM0 Mouse
Cellular Locus
Membrane.
Host
Rabbit
Species Reactivity
Mouse
Immunogen
Recombinant protein within mouse CD41 aa 451-989.
Isotype
IgG
Clone
PSH08-02
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
IHC-P, FC, IF-Cell
Positive Control
Mouse placenta tissue, mouse spleen tissue, mouse plaletets.
Concentration
1 mg/mL
Dilution
IHC-P: 1:200-1:1,000 ;FC: 1:1,000 ;IF-Cell: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 113 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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