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Kallikrein 8 (KLK8) (NM_007196) Human Recombinant Protein

Product Specifications

Background

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Overview

Recombinant protein of human kallikrein-related peptidase 8 (KLK8), transcript variant 1, residues 33-260aa, with C-terminal DDK tag, expressed in sf9 cells.

Synonyms

HNP; NP; NRPN; PRSS19; TADG14

Gene ID

11202

UniProt

O60259

Accession Number mRNA

NM_007196

Chromosomal Location

19q13.41

Expression System

Sf9

Tag

C-DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris-HCl pH8.0, 150mM NaCl, 10%glycerol

Function

Druggable Genome, Secreted Protein, Transmembrane

Molecular Weight

25 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

KLK8

Species

Human

Protein ID

NP_007187

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/11202

Uniprot URL

https://www.uniprot.org/uniprot/O60259

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_007196

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_007187

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