Kallikrein 8 (KLK8) (NM_007196) Human Recombinant Protein
Product Specifications
Background
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Synonyms
HNP; NP; NRPN; PRSS19; TADG14
Gene ID
11202
UniProt
O60259
Accession Number mRNA
NM_007196
Chromosomal Location
19q13.41
Expression System
Sf9
Tag
C-DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris-HCl pH8.0, 150mM NaCl, 10%glycerol
Function
Druggable Genome, Secreted Protein, Transmembrane
Molecular Weight
25 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
KLK8
Species
Human
Protein ID
NP_007187
Overview
Recombinant protein of human kallikrein-related peptidase 8 (KLK8), transcript variant 1, residues 33-260aa, with C-terminal DDK tag, expressed in sf9 cells.
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/11202
Uniprot URL
https://www.uniprot.org/uniprot/O60259
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_007196
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_007187
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