Nicastrin (3F10) Monoclonal Antibody
Product Specifications
Background
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) . It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Synonyms
Nicastrin; NCSTN; KIAA0253; ATAG1874
Gene ID
23385
Swiss Prot
Q92542
Cellular Locus
Extracellular, Membrane bound, Cell membrane
Host
Rabbit
Cross Reactivity
Human
Target
NCSTN
Clonality
Monoclonal
Isotype
IgG
Clone
3F10
Conjugation
Unconjugated
Source
Synthetic peptide within Human Nicastrin aa 650-750 (C terminal) .
Applications
WB
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene ID URL
23385
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