AKR1B15 (NM_001080538) Human Recombinant Protein
Product Specifications
Background
Isoform 1: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:26222439, PubMed:21276782) . In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493) . Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439) . May play a physiological role in retinoid metabolism (PubMed:26222439) .[UniProtKB/Swiss-Prot Function]
Synonyms
AK1R1B7; AKR1B10L; AKR1R1B7
Gene ID
441282
UniProt
C9JRZ8
Accession Number mRNA
NM_001080538
Chromosomal Location
7q33
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, 8M Urea, pH8.0.
Molecular Weight
39.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
AKR1B15
Species
Human
Protein ID
NP_001074007
Overview
Purified recombinant protein of Human aldo-keto reductase family 1, member B15 (AKR1B15), full length, with N-terminal HIS tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/441282
Uniprot URL
https://www.uniprot.org/uniprot/C9JRZ8
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001080538
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001074007
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