AKR1B15 (NM_001080538) Human Recombinant Protein

Product Specifications

Background

Isoform 1: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:26222439, PubMed:21276782) . In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493) . Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439) . May play a physiological role in retinoid metabolism (PubMed:26222439) .[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Human aldo-keto reductase family 1, member B15 (AKR1B15), full length, with N-terminal HIS tag, expressed in E. coli, 50ug

Synonyms

AK1R1B7; AKR1B10L; AKR1R1B7

Gene ID

441282

UniProt

C9JRZ8

Accession Number mRNA

NM_001080538

Chromosomal Location

7q33

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, 8M Urea, pH8.0.

Molecular Weight

39.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.