NR1D1 (NM_021724) Human Recombinant Protein
Product Specifications
Background
This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) . This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]
Synonyms
Ear-1; EAR1; hRev; REVERBA; REVERBalpha; THRA1; THRAL
Gene ID
9572
UniProt
P20393, F1D8S3
Accession Number mRNA
NM_021724
Chromosomal Location
17q21.1
Expression System
E. coli
Tag
N-His
Related Pathways
Circadian rhythm - mammal
Field of Research
Circadian rhythm - mammal
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.
Function
Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
Molecular Weight
66.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NR1D1
Species
Human
Protein ID
NP_068370
Overview
Purified recombinant protein of Human nuclear receptor subfamily 1, group D, member 1 (NR1D1), full length, with N-terminal HIS tag, expressed in E.coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9572
Uniprot URL
https://www.uniprot.org/uniprot/P20393
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_021724
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_068370
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