NR1D1 (NM_021724) Human Recombinant Protein

Product Specifications

Background

This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) . This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]

Overview

Purified recombinant protein of Human nuclear receptor subfamily 1, group D, member 1 (NR1D1), full length, with N-terminal HIS tag, expressed in E.coli, 50ug

Synonyms

Ear-1; EAR1; hRev; REVERBA; REVERBalpha; THRA1; THRAL

Gene ID

9572

UniProt

P20393, F1D8S3

Accession Number mRNA

NM_021724

Chromosomal Location

17q21.1

Expression System

E. coli

Tag

N-His

Related Pathways

Circadian rhythm - mammal

Field of Research

Circadian rhythm - mammal

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.

Function

Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

Molecular Weight

66.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.