NDUFB9 (NM_005005) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a subunit of the mitochondrial oxidative phosphorylation complex I (nicotinamide adenine dinucleotide: ubiquinone oxidoreductase) . Complex I is localized to the inner mitochondrial membrane and functions to dehydrogenate nicotinamide adenine dinucleotide and to shuttle electrons to coenzyme Q. Complex I deficiency is the most common defect found in oxidative phosphorylation disorders and results in a range of conditions, including lethal neonatal disease, hypertrophic cardiomyopathy, liver disease, and adult-onset neurodegenerative disorders. Pseudogenes of this gene are found on chromosomes five, seven and eight. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Overview
Purified recombinant protein of Human NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa (NDUFB9), nuclear gene encoding mitochondrial protein, full length, with N-terminal His tag, expressed in E. coli, 50ug
Synonyms
B22; CI-B22; LYRM3; MC1DN24; UQOR22
Gene ID
4715
UniProt
Q9Y6M9
Accession Number mRNA
NM_005005
Chromosomal Location
8q24.13
Expression System
E. coli
Tag
N-His
Related Pathways
Alzheimer's disease, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease
Field of Research
Alzheimer's disease, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, pH8.0, 8M Urea.
Molecular Weight
21.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NDUFB9
Species
Human
Protein ID
NP_004996
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4715
Uniprot URL
https://www.uniprot.org/uniprot/Q9Y6M9
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005005
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004996
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