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NDUFB9 (NM_005005) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a subunit of the mitochondrial oxidative phosphorylation complex I (nicotinamide adenine dinucleotide: ubiquinone oxidoreductase) . Complex I is localized to the inner mitochondrial membrane and functions to dehydrogenate nicotinamide adenine dinucleotide and to shuttle electrons to coenzyme Q. Complex I deficiency is the most common defect found in oxidative phosphorylation disorders and results in a range of conditions, including lethal neonatal disease, hypertrophic cardiomyopathy, liver disease, and adult-onset neurodegenerative disorders. Pseudogenes of this gene are found on chromosomes five, seven and eight. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Overview

Purified recombinant protein of Human NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa (NDUFB9), nuclear gene encoding mitochondrial protein, full length, with N-terminal His tag, expressed in E. coli, 50ug

Synonyms

B22; CI-B22; LYRM3; MC1DN24; UQOR22

Gene ID

4715

UniProt

Q9Y6M9

Accession Number mRNA

NM_005005

Chromosomal Location

8q24.13

Expression System

E. coli

Tag

N-His

Related Pathways

Alzheimer's disease, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

Field of Research

Alzheimer's disease, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea.

Molecular Weight

21.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

NDUFB9

Species

Human

Protein ID

NP_004996

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/4715

Uniprot URL

https://www.uniprot.org/uniprot/Q9Y6M9

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_005005

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_004996

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