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KLRC4 (NM_013431) Human Recombinant Protein

Product Specifications

Background

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. [provided by RefSeq, Dec 2010]

Overview

Purified recombinant protein of Human killer cell lectin-like receptor subfamily C, member 4 (KLRC4), full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

Synonyms

NKG2-F; NKG2F

Gene ID

8302

UniProt

O43908

Accession Number mRNA

NM_013431

Chromosomal Location

12p13.2

Expression System

E. coli

Tag

N-GST and C-His

Related Pathways

Antigen processing and presentation

Field of Research

Antigen processing and presentation

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea.

Function

Transmembrane

Molecular Weight

46.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

KLRC4

Species

Human

Protein ID

NP_038459

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/8302

Uniprot URL

https://www.uniprot.org/uniprot/O43908

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_013431

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_038459

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