Recombinant IKB beta Monoclonal Antibody
Product Specifications
Background
IkB-beta a protein of the NF-kappa-B inhibitor family. IKB beta Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with IKB beta-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Abbreviation
IKB beta
UniProt
Q15653
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Recombinant human IKB beta fragment
Target
TRIP; NFKBIB; IKBB; TRIP9; I kappa B beta; IkappaBbeta; I-kappa-B-beta; IKB beta; IkB-B; IkBbeta; IkB-beta; NF kappa BIB; NF-kappa-B inhibitor beta; NF-kappa-BIB; Thyroid receptor interacting protein 9; Thyroid receptor-interacting protein 9; TR interacting protein 9; TR-interacting protein 9; TRIP-9
Clonality
Monoclonal,Recombinant
Clone
A563
Conjugation
Unconjugated
Applications
WB; IF; FCM
Field of Research
Signal Transduction; Epigenetics and Nuclear Signaling; Immunology
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; FCM 1:50-1:100; IF 1:50-1:100
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
60 kDa
Observed Molecular Weight
48 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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