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Calpain 1 (CAPN1) (NM_005186) Human Recombinant Protein

Product Specifications

Background

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Overview

Purified recombinant protein of Human calpain 1, (mu/I) large subunit (CAPN1), transcript variant 2, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

Synonyms

CANP; CANP1; CANPL1; muCANP; muCL; SPG76

Gene ID

823

UniProt

P07384

Accession Number mRNA

NM_005186

Chromosomal Location

11q13.1

Expression System

E. coli

Tag

N-GST and C-His

Related Pathways

Alzheimer's disease, Apoptosis

Field of Research

Alzheimer's disease, Apoptosis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea.

Function

Druggable Genome, Protease

Molecular Weight

109.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

CAPN1

Species

Human

Protein ID

NP_005177

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/823

Uniprot URL

https://www.uniprot.org/uniprot/P07384

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_005186

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_005177

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