Calpain 1 (CAPN1) (NM_005186) Human Recombinant Protein
Product Specifications
Background
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Synonyms
CANP; CANP1; CANPL1; muCANP; muCL; SPG76
Gene ID
823
UniProt
P07384
Accession Number mRNA
NM_005186
Chromosomal Location
11q13.1
Expression System
E. coli
Tag
N-GST and C-His
Related Pathways
Alzheimer's disease, Apoptosis
Field of Research
Alzheimer's disease, Apoptosis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, pH8.0, 8M Urea.
Function
Druggable Genome, Protease
Molecular Weight
109.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CAPN1
Species
Human
Protein ID
NP_005177
Overview
Purified recombinant protein of Human calpain 1, (mu/I) large subunit (CAPN1), transcript variant 2, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/823
Uniprot URL
https://www.uniprot.org/uniprot/P07384
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005186
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005177
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