KIF5B (NM_004521) Human Recombinant Protein

Product Specifications

Background

Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity) . Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726) . Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity) .[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Human kinesin family member 5B (KIF5B), Met1-Ile300, with N-terminal His tag, expressed in E. coli, 50ug

Synonyms

HEL-S-61; KINH; KNS; KNS1; UKHC

Gene ID

3799

UniProt

P33176, V9HW29, Q6P164

Accession Number mRNA

NM_004521

Chromosomal Location

10p11.22

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Function

Druggable Genome

Molecular Weight

33.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.