IDO1 Mouse Monoclonal Antibody [Clone ID: LBI4B11]

Product Specifications

Background

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan. [provided by RefSeq, Feb 2011]

Overview

Carrier-free (BSA/glycerol-free) IDO1 mouse monoclonal antibody, clone LBI4B11

Synonyms

IDO; IDO-1; INDO

Gene Name

Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA.

Gene ID

3620

UniProt

P14902

Conjugation

Unconjugated

Related Pathways

Metabolic pathways, Tryptophan metabolism

Field of Research

Metabolic pathways, Tryptophan metabolism

Dilution

WB 1:4000, IHC 1:150, IF 1:100

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.