ALAS1 Mouse Monoclonal Antibody [Clone ID: LBI5D5]

Product Specifications

Background

This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

Overview

Carrier-free (BSA/glycerol-free) ALAS1 mouse monoclonal antibody, clone LBI5D5

Synonyms

ALAS; ALAS-H; ALAS3; ALASH; MIG4

Gene Name

Homo sapiens 5'-aminolevulinate synthase 1 (ALAS1), transcript variant 1, mRNA; nuclear gene for mitochondrial product.

Gene ID

211

UniProt

P13196

Conjugation

Unconjugated

Related Pathways

Glycine, serine and threonine metabolism, Metabolic pathways, Porphyrin and chlorophyll metabolism

Field of Research

Glycine, serine and threonine metabolism, Metabolic pathways, Porphyrin and chlorophyll metabolism

Dilution

WB 1:2000

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.