ALAS1 Mouse Monoclonal Antibody [Clone ID: LBI5D5]
Product Specifications
Background
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Synonyms
ALAS; ALAS-H; ALAS3; ALASH; MIG4
Gene Name
Homo sapiens 5'-aminolevulinate synthase 1 (ALAS1), transcript variant 1, mRNA; nuclear gene for mitochondrial product.
Gene ID
211
UniProt
P13196
Conjugation
Unconjugated
Related Pathways
Glycine, serine and threonine metabolism, Metabolic pathways, Porphyrin and chlorophyll metabolism
Field of Research
Glycine, serine and threonine metabolism, Metabolic pathways, Porphyrin and chlorophyll metabolism
Dilution
WB 1:2000
Form
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Buffer
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Storage Conditions
Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
ALAS1
Overview
Carrier-free (BSA/glycerol-free) ALAS1 mouse monoclonal antibody, clone LBI5D5
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=211
Uniprot URL
https://www.uniprot.org/uniprot/P13196
Curated Selection
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