HHR23b (RAD23B) Mouse Monoclonal Antibody [Clone ID: LBI7G10]

Product Specifications

Background

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER) . This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]

Overview

Carrier-free (BSA/glycerol-free) RAD23B mouse monoclonal antibody, clone LBI7G10

Synonyms

HHR23B; HR23B; P58

Gene Name

Homo sapiens RAD23 homolog B, nucleotide excision repair protein (RAD23B), transcript variant 1, mRNA.

Gene ID

5887

UniProt

P54727

Conjugation

Unconjugated

Related Pathways

Nucleotide excision repair

Field of Research

Nucleotide excision repair

Dilution

WB 1:500, IHC 1:150

Form

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Buffer

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Function

Druggable Genome

Storage Conditions

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.