SDHB Mouse Monoclonal Antibody [Clone ID: LBI1H6]
Product Specifications
Background
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]
Overview
SDHB mouse monoclonal antibody, clone LBI1H6
Synonyms
CWS2; IP; MC2DN4; PGL4; SDH; SDH1; SDH2; SDHIP
Gene Name
Succinate dehydrogenase complex iron sulfur subunit B
Gene ID
6390
UniProt
P21912
Conjugation
Unconjugated
Related Pathways
Alzheimer's disease, Citrate cycle (TCA cycle), Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease
Field of Research
Alzheimer's disease, Citrate cycle (TCA cycle), Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease
Concentration
1 mg/ml
Dilution
WB 1:2000, IHC 1:150
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
SDHB
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=6390
Uniprot URL
https://www.uniprot.org/uniprot/P21912
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