Cardiac Troponin I (TNNC1) Mouse Monoclonal Antibody [Clone ID: LBI5H3]
Selected Variant
AMM16502V
Size: 100 µL
Product Specifications
Background
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]
Overview
TNNC1 mouse monoclonal antibody, clone LBI5H3
Synonyms
CMD1Z; CMH13; TN-C; TNC; TNNC
Gene Name
Troponin C1, slow skeletal and cardiac type
Gene ID
7134
UniProt
P63316
Conjugation
Unconjugated
Related Pathways
Calcium signaling pathway, Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)
Field of Research
Calcium signaling pathway, Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)
Concentration
1 mg/ml
Dilution
IHC 1:150
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
TNNC1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=7134
Uniprot URL
https://www.uniprot.org/uniprot/P63316
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