TrkC (NTRK3) Mouse Monoclonal Antibody [Clone ID: LBI19B8]

Product Specifications

Background

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.

Overview

Anti-NTRK3 (TrkC) mouse monoclonal antibody, clone LBI19B8

Synonyms

GP145-TrkC; TRKC; gp145 (trkC)

Gene Name

Neurotrophic receptor tyrosine kinase 3

Gene ID

4916

UniProt

Q16288

Conjugation

Unconjugated

Related Pathways

Neurotrophin signaling pathway

Field of Research

Neurotrophin signaling pathway

Concentration

1 mg/ml

Dilution

WB 1:500

Form

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome, Protein Kinase, Transmembrane

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.