ROS1 Antibody [AMM22254G]
Product Specifications
Background
Tissue Location: Expressed in brain. Expression is increased in primary gliomas.
Synonyms
Proto-oncogene tyrosine-protein kinase ROS, 2.7.10.1, Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, Receptor tyrosine kinase c-ros oncogene 1, c-Ros receptor tyrosine kinase, ROS1, MCF3, ROS
Gene Name
ROS1
Gene ID
6098
UniProt
P08922
Chromosomal Location
Cell membrane; Single-pass type I membrane protein
Applications
WB
Dilution
WB--1:4000 IHC--1:250
Function
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
Molecular Weight
263915
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ROS1 Antibody [AMM22254G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=6098
Uniprot URL
https://www.uniprot.org/uniprot/P08922
Available Sizes
Curated Selection
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