CHM Antibody - N-terminal region : FITC (AVARP13011_P050-FITC)
Selected Variant
AVARP13011_P050-FITC
Size: 100 µL
Product Specifications
Gene Name
Choroideremia (Rab escort protein 1)
Gene Aliases
TCD, GGTA, REP-1, DXS540, HSD-32
Gene ID
1121
Swiss Prot
P24386
Accession Number
NP_000381
Host
Rabbit
Reactivity
Human, Horse
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human CHM
Target
CHM binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.The choroideremia gene encodes for a protein, the Rab escort protein-1 (REP1), which is involved in membrane trafficking.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Partner Proteins
UBC; RAB1B; RAB32; RAB14; RAB3D; RAB7A; RAB18; RAB5B; RAB6A; RAB4A; RAB3B; RAB3A; RAB5A; RAB1A
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Concentration
0.5 mg/ml
Homology
Horse: 80%; Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
73kDa
References & Citations
Fujita, Y., (2008) Invest. Ophthalmol. Vis. Sci. 49 (4), 1315-1321
Shipping Conditions
Wet Ice
Protein Length
653
NCBI Gene Symbol
CHM
NCBI GB Accession Number
CHM
Host or Source
Rabbit
Protein Name
Rab proteins geranylgeranyltransferase component A 1
Nucleotide Accession Number
NM_000390
Peptide Sequence
LHVDSRSYYGGNWASFSFSGLLSWLKEYQENSDIVSDSPVWQDQILENEE
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