DOK1 Antibody - C-terminal region : FITC (AVARP09001_P050-FITC)

DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.

UBC; RASA1; ABL1; CD28; Nck1; Syngap1; INSR; CRKL; BCR; Dlg4; gag-pol; ERBB2; VAV1; SRC; SHC1; PTK6; PIK3R1; ITK; FGR; CRK; ABL2; CBLL1; INPP5D; NCK2; MAP4K4; PTPRH; GRB10; TEC; ITGB2; SH2D1A; FES; PTPN6; ITGB3; PLCG1; LYN; KIT; YES1; RET; LCK; ITGB5; ITG

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.