RIC8A Antibody - N-terminal region : FITC (ARP57567_P050-FITC)
Selected Variant
ARP57567_P050-FITC
Size: 100 µL
Product Specifications
Gene Name
Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
Gene Aliases
RIC8
Gene ID
60626
Swiss Prot
Q9NPQ8-3
Accession Number
NP_068751
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human RIC8A
Target
RIC8A is a guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins.RIC8A is able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP.RIC8A is involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G (i) -alpha protein, possibly leading to release G (i) -alpha-GTP and NuMA proteins from the NuMA-GPSM2-G (i) -alpha-GDP complex. RIC8A also acts as an activator for G (q) -alpha (GNAQ) protein by enhancing the G (q) -coupled receptor-mediated ERK activation.
Partner Proteins
NECAB2; UBQLN1; RABAC1; UBC; EFEMP1; SDCBP; NUTM1; SARNP; WDR61; DPP7; PAPSS2; EZR; UBA1; RPL38; PYGB; PLCG1; MC1R; APEX1; GNAQ; XPO1; GNAI1; UBQLN4; ZNF585B; RIC8A; MAPK8IP3; GNA13; TERF1; GNAI3; GNAI2; GNAS; GNAO1; TUBB2A
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
60kDa
Shipping Conditions
Wet Ice
Protein Length
537
NCBI Gene Symbol
RIC8A
NCBI GB Accession Number
RIC8A
Host or Source
Rabbit
Protein Name
Synembryn-A
Nucleotide Accession Number
NM_021932
Peptide Sequence
KLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLL
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