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RMI1 Antibody - N-terminal region : HRP (ARP46340_P050-HRP)

Selected Variant

ARP46340_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)

Gene Aliases

BLAP75, FAAP75, C9orf76

Gene ID

80010

Swiss Prot

Q9H9A7

Accession Number

NP_079221

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human RMI1

Target

RMI1 is an essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. RMI1 promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. RMI1 is required for BLM phosphorylation during mitosis. Within the BLM complex, RMI1 is required for BLM and TOP3A stability.RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions (Raynard et al., 2006 [PubMed 16595695]) .[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-136 BP327553.1 1-136 137-885 DN997105.1 9-757 886-2740 AL732446.4 14777-16631 2741-3508 BC039999.2 2566-3333

Partner Proteins

APITD1; STRA13; UBC; RPA3; RPA2; RPA1; TOPBP1; BLM; NR1H2; UBE3A; HSPA13; PFDN1; Ercc6l; Top3a; FANCM; RMI2; FANCF; RMI1; FANCA

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 93%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

70kDa

References & Citations

Broberg, K., (2007) Cancer Lett. 258 (1), 38-44

Shipping Conditions

Wet Ice

Protein Length

625

NCBI Gene Symbol

RMI1

NCBI GB Accession Number

RMI1

Host or Source

Rabbit

Protein Name

RecQ-mediated genome instability protein 1

Nucleotide Accession Number

NM_024945

Peptide Sequence

DGILEIPKGELNGFYALQINSLVDVSQPAYSQIQKLRGKNTTNDLVTAEA

Price

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