Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Bag1 Antibody Picoband®

Selected Variant

A02423-2

Size: 100 µg/Vial

Boster Bio Anti-Bag1 Antibody Picoband® catalog # A02423-2. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

BAG family molecular chaperone regulator 1 (BAG1) is a protein that in humans is encoded by the BAG1 gene. Human BAG1 is mapped to chromosome 9p12, a region associated with hereditary disorders that may involve developmental dysregulation of programmed cell death. The Bag1 protein is rich in glutamic acid residues. Its deduced 274-amino acid protein has a calculated molecular mass of 31 KD. Being the BCL-2-associated athanogene, Bag1 enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms.

Synonyms

BAG family molecular chaperone regulator 1; BAG-1; Bcl-2-associated athanogene 1; BAG1; HAP

Gene Name

BAG1

Gene ID

573

UniProt

Q99933

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Bag1, different from the related mouse sequence by two amino acids, and from the related rat sequence by three amino acids.

Clonality

Polyclonal

Tissue Specificity

Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level) . .

Applications

IHC, WB

Field of Research

Apoptosis, Apoptotic Markers, Atherosclerosis, Cancer, Cardiovascular, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. .

References & Citations

1. Takayama S, Sato T, Krajewski S, Kochel K, Irie S, Millan JA, Reed JC (Mar 1995) . Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell 80 (2) : 279–84. 2. Takayama, S., Kochel, K., Irie, S., Inazawa, J., Abe, T., Sato, T., Druck, T., Huebner, K., Reed, J. C.Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12.Genomics35: 494-498, 1996. 3. Entrez Gene: BAG1 BCL2-associated athanogene.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

38779 MW

Observed Molecular Weight

33, 46, 56 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

BAG family molecular chaperone regulator 1

Subcellular Location

Isoform 1: Nucleus. Cytoplasm. Isoform 1 localizes predominantly to the nucleus.

Protein Name

BAG family molecular chaperone regulator 1

Isotype

Rabbit IgG

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Price

Sign In for Pricing

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Anti-TMEM16A/ANO1 Antibody Picoband®, HRP Conjugate
A00713-HRP 100 µg/Vial

Anti-TMEM16A/ANO1 Antibody Picoband®, HRP Conjugate

Sign In for Pricing
View Details
Mouse KIM1 / TIM1 ELISA Kit PicoKine®
EK0880 96 Well With Removable Strips

Mouse KIM1 / TIM1 ELISA Kit PicoKine®

Sign In for Pricing
View Details
AFP (Alpha Fetoprotein) (C2), CF640R conjugate, 0.1mg/mL
BNC400523-500 1x 500 µL

AFP (Alpha Fetoprotein) (C2), CF640R conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Anti-SYBL1/VAMP7 Antibody Picoband® (HRP Conjugate)
PB10017-HRP 100 µg/Vial

Anti-SYBL1/VAMP7 Antibody Picoband® (HRP Conjugate)

Sign In for Pricing
View Details
BCL10 (MALT-Lymphoma Marker) (151), CF647 conjugate, 0.1mg/mL
BNC471852-100 1x 100 µL

BCL10 (MALT-Lymphoma Marker) (151), CF647 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Cytokeratin 5/6/18 (LP34), CF647 conjugate, 0.1mg/mL
BNC472036-500 1x 500 µL

Cytokeratin 5/6/18 (LP34), CF647 conjugate, 0.1mg/mL

Sign In for Pricing
View Details