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PPP4R2 Antibody - C-terminal region : Biotin (ARP42719_P050-Biotin)

Product Specifications

Gene Name

Protein phosphatase 4, regulatory subunit 2

Gene Aliases

PP4R2

Gene ID

151987

Swiss Prot

Q9NY27

Accession Number

NP_777567

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human PPP4R2

Target

PPP4R2 is the regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) . It may regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.

Partner Proteins

UBC; PAAF1; SMEK1; SF3A1; CCDC6; VASP; CCT3; PSMA1; INPPL1; AMPD2; LRRC47; DSTN; PLIN3; NUBP2; TPM1; TRA2B; IGBP1; CLNS1A; PPP4C; SRRM2; TIPRL; SMEK2; GEMIN4; DDX20

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

PPP4R2 is supported by BioGPS gene expression data to be expressed in Jurkat

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

47kDa

References & Citations

Ewing, R.M., Mol. Syst. Biol. 3, 89 (2007)

Shipping Conditions

Wet Ice

Product Datasheet

Anti-PPP4R2 (ARP42719_P050-Biotin) antibody

Protein Length

417

NCBI Gene Symbol

PPP4R2

NCBI GB Accession Number

PPP4R2

Host or Source

Rabbit

Protein Name

Serine/threonine-protein phosphatase 4 regulatory subunit 2

Nucleotide Accession Number

NM_174907

Peptide Sequence

DSRCTRQHCTEEDEEEDEEEEEESFMTSREMIPERKNQEKESDDALTVNE

Subunit

2

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