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DLAT Antibody - N-terminal region : HRP (ARP41994_T100-HRP)

Selected Variant

ARP41994_T100-HRP

Size: 100 µL

Product Specifications

Gene Name

Dihydrolipoamide S-acetyltransferase

Gene Aliases

E2, PBC, DLTA, PDCE2, PDC-E2

Gene ID

1737

Swiss Prot

P10515

Accession Number

NP_001922

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human DLAT

Target

DLAT is dihydrolipoamide acetyltransferase, the E2 subunit of the mammalian pyruvate dehydrogenase complex of the inner mitochondrial membrane. Patients with primary biliary cirrhosis show autoantibodies to DLAT.The DLAT gene encodes dihydrolipoamide acetyltransferase (EC 2.3.1.12), the E2 subunit of the mammalian pyruvate dehydrogenase complex (PDC; EC 1.2.4.1) of the inner mitochondrial membrane. Patients with primary biliary cirrhosis (PBC; MIM 109720) show autoantibodies to DLAT.[supplied by OMIM].

Partner Proteins

MDM2; UBC; ADRB2; PRKD3; PDHX; MMGT1; MRPL1; ACAD9; SYNCRIP; PDHA2; PDHA1; OGDH; NDUFS4; HSPA1L; DLD; COX5B; COPS5; CUL1; SIRT7; TSG101; KIAA0101; PSMA3; PDK4; PDK3; PDK2; PDK1; PDHB

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IHC, WB

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

69kDa

References & Citations

Head, R.A., (2005) Ann. Neurol. 58 (2), 234-241

Shipping Conditions

Wet Ice

Protein Length

647

NCBI Gene Symbol

DLAT

NCBI GB Accession Number

DLAT

Host or Source

Rabbit

Protein Name

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Nucleotide Accession Number

NM_001931

Peptide Sequence

WTPSSGATPRNRLLLQLLGSPGRRYYSLPPHQKVPLPSLSPTMQAGTIAR

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