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WWTR1 Antibody - N-terminal region : HRP (ARP32540_P050-HRP)

Selected Variant

ARP32540_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

WW domain containing transcription regulator 1

Gene Aliases

TAZ

Gene ID

25937

Swiss Prot

Q9GZV5

Accession Number

NP_056287

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human WWTR1

Target

TAZ (transctiptional coactivator with PDZ-binding motif), also known as WW domain containing transcription regulator 1 (WWTR1), is a member of the bicoid sub-family of homeodomain-containing transcription factors. TAZ is a 14-3-3 binding protein that co-activates Runx2-dependent gene transcription while repressing PPAR-gamma-dependent gene transcription. TAZ has been reported to be a modulator of mesenchymal stem cell differentiation. TAZ may also play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined.

Partner Proteins

MED28; NOTCH1; YWHAQ; LATS1; BTRC; YWHAE; TP53BP2; PPP1CA; KLF5; YWHAZ; YWHAG; PAX3; SLC9A3R2; TEAD3; TEAD4; NKX2-1; RUNX1

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

44kDa

References & Citations

Hong, J., et al., (2005) Science, 309 (5737),1074-1078

Shipping Conditions

Wet Ice

Protein Length

400

NCBI Gene Symbol

WWTR1

NCBI GB Accession Number

WWTR1

Host or Source

Rabbit

Protein Name

WW domain-containing transcription regulator protein 1

Nucleotide Accession Number

NM_015472

Peptide Sequence

PRLAGGAQHVRSHSSPASLQLGTGAGAAGSPAQQHAHLRQQSYDVTDELP

Price

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