SIRT1 Antibody - N-terminal region : Biotin (ARP32386_T100-Biotin)
Product Specifications
Gene Name
Sirtuin 1
Gene Aliases
SIR2, SIR2L1, SIR2alpha
Gene ID
23411
Swiss Prot
Q96EB6
Accession Number
NP_036370
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human SIRT1
Target
SIRT1 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family.
Partner Proteins
SIRT2; KAT5; IRS1; ING2; ING1; HSP90AA1; AR; EP300; CDK1; CCNB1; RPS19BP1; KAT8; CLOCK; IRS2; UBE2I; TP53; STK11; WRN; PPARGC1A; FOXO1; VHL; UBC; E2F1; PSME3; KCNA5; KCNA4; KCNAB2; POP1; PPARA; CAP1; KIAA1598; TPM4; FASN; CDKL1; HIC1; HDAC4; CHD3; CDK6; S
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
82kDa
References & Citations
Solomon, J.M., et al., (2006) Mol. Cell. Biol. 26 (1), 28-38
Shipping Conditions
Wet Ice
Product Datasheet
Anti-SIRT1 (ARP32386_T100-Biotin) antibody
Protein Length
747
NCBI Gene Symbol
SIRT1
NCBI GB Accession Number
SIRT1
Host or Source
Rabbit
Protein Name
NAD-dependent protein deacetylase sirtuin-1
Nucleotide Accession Number
NM_012238
Peptide Sequence
PETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKI
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
