(R) -Birabresib

(R) -Birabresib is the isomer of Birabresib (HY-15743), and can be used as an experimental control. Birabresib (OTX-015) is a potent bromodomain (BRD2/3/4) inhibitor with IC50s ranging from 92 to 112 nM.

Product Specifications

CAS Number

[1983196-25-3]

Product Name Alternative

(R) -OTX-015; (R) -MK-8628

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Isomer

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/r-birabresib.html

Purity

99.94

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(C(C2=C(N3C4=NN=C3C)SC(C)=C2C)=N[C@@H]4CC(NC5=CC=C(O)C=C5)=O)C=C1

Molecular Formula

C25H22ClN5O2S

Molecular Weight

491.99

Precautions

H302, H315, H319, H335

References & Citations

[1]Marie-Magdelaine Coudé, et al. BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells. Oncotarget. 2015 Jul 10; 6 (19) : 17698–17712.|[2]Lu P, et al. The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb. Sci Rep. 2016 Apr 12;6:24100|[3]Vázquez R, et al. The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with RAD001. Oncotarget. 2017 Jan 31;8 (5) :7598-7613.|[4]J. Kay Noel, et al. Abstract C244: Development of the BET bromodomain inhibitor OTX015. Mol Cancer Ther November 2013 12; C244.