SHP2-IN-5

SHP2-IN-5 (compound 1) is an inhibitor of SHP2 (IC50: 97 nM) . SHP2 is a non-receptor protein tyrosine phosphatase associated with cell growth and proliferation. SHP2-IN-5 has the potential to inhibit cancer and SHP2-related human diseases[1].

Product Specifications

CAS Number

[54755-93-0]

UNSPSC

12352005

Target

SHP2

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/shp2-in-5.html

Solubility

10 mM in DMSO

Smiles

OC1=CC=C(C=C(C(O)=O)C=C(O)C2=O)C2=C1O

Molecular Formula

C12H8O6

Molecular Weight

248.19

References & Citations

[1]Kim B, et al. Development and structure-activity relationship study of SHP2 inhibitor containing 3, 4, 6-trihydroxy-5-oxo-5H-benzo [7] annulene[J]. Bioorganic & Medicinal Chemistry Letters, 2020, 30 (1) : 126756.. . .