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PCI-34051

PCI-34051 is a potent and selective HDAC8 inhibitor with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms.

Product Specifications

CAS Number

950762-95-5

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PCI-34051.html

Purity

99.84

Solubility

DMSO : ≥ 30 mg/mL

Smiles

COC(C=C1)=CC=C1CN2C3=CC(C(NO)=O)=CC=C3C=C2

Molecular Formula

C17H16N2O3

Molecular Weight

296.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Balasubramanian S, et al. A novel histone deacetylase 8 (HDAC8) -specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas. Leukemia. 2008 May;22 (5) :1026-34.|[2]Ren Y, et al. Therapeutic effects of histone deacetylase inhibitors in a murine asthma model. Inflamm Res. 2016 Dec;65 (12) :995-1008.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HDAC1; HDAC10; HDAC6; HDAC8

Available Sizes

Frequently Asked Questions

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