LCS-1
LCS-1 is a superoxide dismutase 1 (SOD1) inhibitor. LCS-1 inhibits SOD1 activity with an IC50 value of 1.07 μM. LCS-1 induces the early- and late-stage apoptosis of multiple myeloma (MM.1S) cells[1][2][3].
Product Specifications
CAS Number
[41931-13-9]
Product Name Alternative
MK-0364 (racemate),R816
UNSPSC
12352005
Hazard Statement
H301, H319
Target
Apoptosis; SOD
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lcs-1.html
Concentration
10mM
Purity
99.81
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C(Cl)=C(Cl)C=NN1C2=CC=CC(C)=C2
Molecular Formula
C11H8Cl2N2O
Molecular Weight
255.10
Precautions
H301, H319
References & Citations
[1]Gupta A, et al. Nanocarrier Composed of Magnetite Core Coated with Three Polymeric Shells Mediates LCS-1 Delivery for Synthetic Lethal Therapy of BLM-Defective Colorectal Cancer Cells. Biomacromolecules. 2018 Mar 12;19 (3) :803-815.|[2]Somwar R, et al. Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines. Proc Natl Acad Sci U S A. 2011;108 (39) :16375-16380.|[3]Du T, et al. Proteomic analysis identifies mechanism (s) of overcoming bortezomib resistance via targeting ubiquitin receptor Rpn13. Leukemia. 2021 Feb;35 (2) :550-561.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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