CD35 monoclonal antibody

Product Specifications

Background

Complement receptor type 1` (CR1; CD35) is a type I transmembrane glycoprotein that is expressed on the surface of B cells, neutrophils, monocytes and renal podocytes. As a component of the host innate immune system, CR1/CD35 expressed on neutrophils and monocytes binds to ligands coated with the complement opsonins, C3b and C4b, which facilitates phagocytosis and production of proinflammatory cytokines. CR1/CD35 also participates in negative regulation of the complement cascade through its ability to promote dissociation of C3 and C5 convertases and by serving as one of multiple cofactors for Factor-I-mediated cleavage and inactivation of C3b and C4b.

CAS Number

9007-83-4

Structure Composition

Mouse IgG1. Liquid in PBS, pH 7.3, and 0.02% sodium azide.

Product Name Alternative

C3BR; Complement receptor type 1; C3b/C4b receptor; CD antigen CD35

Swiss Prot

P17927

Reactivity

Human

Immunogen

Native purified human CD35.

Conjugation

Unconjugated

Applications

IF, FC

Dilution

IF (1/50 - 1/200)

Purity

The monoclonal antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .